Oral metronidazoleSome Trade Names FLAGYL Click for Drug Monograph is absorbed well. It is usually given IV only if patients cannot be treated orally. It is distributed widely in body fluids and penetrates into CSF, resulting in high concentrations. MetronidazoleSome Trade Names FLAGYL Click for Drug Monograph is metabolized presumably in the liver and excreted mainly in urine, but elimination is not decreased in patients with renal insufficiency.
MetronidazoleSome Trade Names FLAGYL Click for Drug Monograph is in pregnancy category B (animal studies show no risk and human evidence is incomplete, or animal studies show risk but human studies do not). Nonetheless, metronidazoleSome Trade Names FLAGYL Click for Drug Monograph should be avoided during the 1st trimester because mutagenicity is a concern.
Nausea, vomiting, headache, seizures, syncope, other CNS effects, and peripheral neuropathy can occur; rash, fever, and reversible neutropenia have been reported. MetronidazoleSome Trade Names FLAGYL Click for Drug Monograph can cause a metallic taste and dark urine. A disulfiramSome Trade Names ANTABUSE Click for Drug Monograph -like reaction may occur if alcohol is ingested within 7 days of use.
Dosing Considerations
MetronidazoleSome Trade Names FLAGYL Click for Drug Monograph doses are not decreased in patients with renal failure but are usually decreased 50% in patients with significant liver disease.
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